Anesthesiology
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Duration of pre-operative fasting in children is associated with increased risk of post-induction hypotension.
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Review Case Reports
Determining Associations and Estimating Effects with Regression Models in Clinical Anesthesia.
There are an increasing number of "big data" studies in anesthesia that seek to answer clinical questions by observing the care and outcomes of many patients across a variety of care settings. This Readers' Toolbox will explain how to estimate the influence of patient factors on clinical outcome, addressing bias and confounding. One approach to limit the influence of confounding is to perform a clinical trial. ⋯ Logistic regression is used when the outcome is binary (e.g., intracranial hemorrhage: yes or no), by modeling the natural log for the odds of an outcome. Because outcomes are influenced by many factors, we commonly use multivariable logistic regression to estimate the unique influence of each factor. From this tutorial, one should acquire a clearer understanding of how to perform and assess multivariable logistic regression.
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Randomized Controlled Trial Multicenter Study
Anesthesia and Circulating Tumor Cells in Primary Breast Cancer Patients: A Randomized Controlled Trial.
Type of maintenance anesthesia, whether propofol or sevoflurane, had no effect on circulating tumor cell count after primary breast cancer surgery.
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Comparative Study
Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine.
To improve understanding of the respiratory behavior of oliceridine, a μ-opioid receptor agonist that selectively engages the G-protein-coupled signaling pathway with reduced activation of the β-arrestin pathway, the authors compared its utility function with that of morphine. It was hypothesized that at equianalgesia, oliceridine will produce less respiratory depression than morphine and that this is reflected in a superior utility. ⋯ These data indicate a favorable oliceridine safety profile over morphine when considering analgesia and respiratory depression over the clinical concentration range.