Anesthesia and analgesia
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Anesthesia and analgesia · Jun 2010
Randomized Controlled TrialPropofol reduces the distribution and clearance of midazolam.
Midazolam, at sedative levels, increases blood propofol concentrations by 25%. We evaluated the reverse interaction and determined the influence of propofol on the pharmacokinetics of midazolam. ⋯ Propofol reduces the distribution and clearance of midazolam in a concentration-dependent manner. In addition, inclusion of heart rate as a covariate improved the pharmacokinetic model of midazolam predominantly through a reduction in the intraindividual variability.
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Anesthesia and analgesia · Jun 2010
Randomized Controlled TrialPerioperative glucose and insulin administration while maintaining normoglycemia (GIN therapy) in patients undergoing major liver resection.
Although hyperglycemia is a well-recognized risk factor in the context of cardiac surgery, the relevance of perioperative glycemic control for patients undergoing major noncardiac operations has received little attention. We designed this study to assess the hyperglycemic response to liver resection, and to test the hypothesis that perioperative glucose and insulin administration while maintaining normoglycemia (GIN therapy) provides glycemic control superior to that achieved by the conventional use of insulin. ⋯ GIN therapy effectively provides normoglycemia in patients undergoing liver resection (clinicaltrials.gov, NCT00774098).