Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Dec 2000
Randomized Controlled Trial Clinical TrialEffect of pre-emptive hydromorphone administration on postoperative pain relief--a randomized controlled trial.
Pre-emptive analgesia represents a treatment strategy which tries to prevent the development of pain by inhibiting central reactions to peripheral sensory stimuli. In a prospective randomized double-blind placebo-controlled study, the effect of oral premedication with 4 mg of a slow-release hydromorphone preparation on postoperative piritramide consumption and subjective pain perception is being evaluated. ⋯ In our study, oral administration of 4 mg of slow-release hydromorphone did not show any greater pre-emptive analgesic effect than placebo.