Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Oct 2010
Multicenter StudyLower prevalence of common filaggrin mutations in a community sample of atopic eczema: is disease severity important?
Recent studies have shown an association of loss-of-function mutations in the filaggrin gene (FLG) with ichthyosis vulgaris and atopic eczema (AE). Case selection may have distorted the hitherto reported prevalence of FLG mutations and their relation to atopic disease. The aim of the study was to determine the true population prevalence of FLG mutations in unselected children with and without reported physician diagnoses of asthma, allergic rhinitis and AE and their relationship with family history of atopic disease. ⋯ Case selection may be responsible for overestimating the prevalence of FLG mutations in atopic disease.
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Wien. Klin. Wochenschr. · Oct 2010
Multicenter StudyVariability of structures in German intensive care units--a representative, nationwide analysis.
Structures in intensive care medicine comprise human as well as material resources, organization, and management and may be related to processes thereby affecting patients' outcomes. Utilizing a unique data base we evaluated structures of German intensive care units (ICUs). ⋯ In a representative, nationwide sample of German ICUs key elements of structures varied considerably with respect to hospital size. This has to be considered when proposing standards, reimbursement strategies, or quality assessment.