Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Apr 2021
ReviewMutant strains of SARS-CoV-2 are more prone to infect obese patient: a review.
The current review critically analyzes obesity as an important risk factor for increased predisposition towards coronavirus disease 2019 (COVID-19), its severity and causal death in current pandemic. Countries with higher prevalence of exposed obese individuals experienced the highest number of mortalities. The analysis also proved that individuals having more adipose tissue in body have a higher level of angiotensin-converting enzyme 2 (ACE2), which is identified as functional receptor for COVID-19. ⋯ Furthermore, in silico interactions of ACE2 and different variants of coronavirus 2 (CoV-2) spike S1 protein suggest that mutant strains are more infectious than wildtype as they bind to host ACE2 protein with high binding affinities. Certain specific cancers including cervical cancer, pancreatic and rectal adenocarcinomas have more expression of such receptors and pose additional risk to already immunocompromised cancer patients. This review emphasizes obesity, as the covert risk factor of COVID-19 infection and sensitizes about of calorie restrictions, immunity building and preventive measures.
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Wien. Klin. Wochenschr. · Apr 2021
COVID-19 lock-down significantly reduced number of surgical presentations in an emergency department.
Coronavirus disease 2019 (COVID-19) is an acute virus infection, which was declared by the World Health Organization (WHO) as a pandemic. As a consequence, the Swiss government decreed a public lock-down to reduce and restrict further infections. The aim of this investigation was to provide the impact of the COVID-19 lock-down on the presentations of patients in an interdisciplinary emergency department (ED). ⋯ The socioeconomic lock-down was associated with reduced number of presentations in an ED. Mainly, surgical diseases and injuries were affected in terms of a reduction of presentations during the COVID-19 lock-down period.
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Wien. Klin. Wochenschr. · Apr 2021
ReviewClinical manifestations of COVID-19 in the general population: systematic review.
Clinical manifestations of COVID-19 are varied in the general population. This study aimed to systematize the literature regarding clinical manifestations of patients with confirmed COVID-19. A systematic review of the literature was conducted. ⋯ In studies with more than 100 patients, the 3 main symptoms were fever (57.93%), cough (54.21%), and dyspnea (30.64%). Dermatological manifestations do not appear among the main symptoms. The identification of all clinical manifestations of COVID-19 is essential for an early diagnosis and the adoption of preventive measures.
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Wien. Klin. Wochenschr. · Apr 2021
[Pellagra-originally described in the Austrian Empire 250 years ago became a fatal endemic in some provinces].
Pellagra is characterized by "dermatitis - diarrhea - dementia - death". Various causes were discussed over the course of two centuries. The initial presumption was that the sun caused changes in exposed areas of the body. ⋯ It was also important to educate the population about preventing pellagra by consuming proper food. Pellagra funds to sustain the measures were established. In the provinces, pellagra commissions, chaired by the governor and consisting of twelve experts of the relevant medical branches, were appointed as an advisory and expert body.