Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Jul 2021
Outcomes of an HCV elimination program targeting the Viennese MSM population.
Recent reports suggest an increasing incidence of hepatitis C virus (HCV) infections among MSM (men-who-have-sex-with-men). Early treatment with direct-acting antivirals (DAAs) achieves high cure rates and prevents further HCV transmission. We offered barrier-free HCV screening in the Viennese MSM population and immediate access to DAA treatment. ⋯ A targeted HCV test-and-treat program revealed a high prevalence of HCV seropositivity among Viennese MSM, potentially associated with high-risk sexual behavior and drug use. Early DAA treatment seems warranted in viremic HCV-MSM as SVR was 100%, which in turn prevents further HCV transmission.
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Wien. Klin. Wochenschr. · Jul 2021
ReviewImmunotherapy and vaccination against infectious diseases.
Due to the overuse of antibiotics, infections, in particular those caused by multidrug-resistant bacteria, are becoming more and more frequent. Despite the worldwide introduction of antibiotic therapy, vaccines and constant improvements in hygiene, the burden of multidrug-resistant bacterial infections is increasing and is expected to rise in the future. The development of monoclonal therapeutic antibodies and specific immunomodulatory drugs represent new treatment options in the fight against infectious diseases. This article provides a brief overview of recent advances in immunomodulatory therapy and other strategies in the treatment of infectious disease.
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Wien. Klin. Wochenschr. · Jul 2021
Observational StudyRisk factors for mortality in infants with congenital diaphragmatic hernia: a single center experience.
Despite current progress in research of congenital diaphragmatic hernia, its management remains challenging, requiring an interdisciplinary team for optimal treatment. ⋯ The survival rate in this cohort is comparable to the current literature. Parameters such as the side of the diaphragmatic defect, duration of ECMO and inhaled nitric oxide were assessed as mortality risk factors. This analysis of patients with congenital diaphragmatic hernia enhances understanding of risk factors for mortality, helping to improve management and enabling further evaluation in prospective clinical trials.
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Wien. Klin. Wochenschr. · Jul 2021
Observational StudyRole of multi-detector computed tomography in severity assessment of cases of acute pancreatitis.
The mortality and morbidity of acute pancreatitis is high, especially in the severe variant. The present study was performed to study the role of multi-detector computed tomography (MDCT) in grading the severity of acute pancreatitis and to compare the scoring system with the revised Atlanta classification (RAC) and with the outcomes of acute pancreatitis. ⋯ The MDCT is a very useful investigation in the diagnosis and management of acute pancreatitis. The threshold to opt for MDCT imaging in acute pancreatitis should be low for performing the timely interventions required in acute pancreatitis.
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Wien. Klin. Wochenschr. · Jul 2021
Neurodevelopmental outcome of very preterm infants with gastrointestinal tract perforations does not differ compared to controls.
To evaluate gastrointestinal tract (GIT) perforations in very low birth weight infants and the effects on neurodevelopmental outcome. ⋯ Despite increased morbidities preterm infants with GIT perforation did not have a higher mortality rate and groups did not differ regarding neurodevelopmental outcome at the corrected for prematurity age of 2 years.