Wiener klinische Wochenschrift
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Patients who are Jehovah's Witnesses present a special problem when undergoing open heart surgery since they refuse blood transfusion. We performed 15 open heart operations for both acquired and congenital heart disease using a modified version of isovolaemic haemodilution and bloodless prime technique of extracorporeal circulation. ⋯ One death might have been at least indirectly related to the regimen which excludes blood substitution. We believe that our experience demonstrates the feasibility of open heart procedures in Jehovah's Witnesses, although the mortality risk is increased in these patients.
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Although the anaesthetizing effect of cocaine had been known for a long time, it was only in 1884 that Karl Koller first carried out animal experiments, followed by clinical testing in humans of the anaesthetic effect of cocaine on the eye. Freud had shortly before directed the attention of Viennese doctors to the alkaloid cocaine in a paper. Upon Freud's suggestion Königstein tested the effect of cocaine therapeutically, whilst Koller independently conceived the use of cocaine as a local anaesthetic for eye operations. Jelinek introduced cocaine into laryngology and Wölfler into surgery, as further applications for the use of this local anaesthetic.
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Wien. Klin. Wochenschr. · Mar 1985
Randomized Controlled Trial Comparative Study Clinical Trial[Comparative study on the effect of diet, exercise and iodine balneotherapy on blood rheologic parameters in diabetics within the scope of a 4 week health resort stay in Bad Hall].
A total of 123 spa patients with inadequately controlled diabetes mellitus was divided into the following 3 therapeutic groups: 1. therapeutic exercise alone, 2. iodine therapy with iodine brine (including drinking cure with "iodine-brine concentrate"), 3. remedial exercise plus iodine brine therapy. All patients received a rigidly controlled diabetic diet. The following parameters were determined at the beginning and at the end of the cure: whole blood and plasma viscosity, fibrinogen, blood glucose, total and HDL-cholesterol, triglycerides, HbA1c, alpha 2-macroglobulin, total protein, microhaematocrit. ⋯ The largest decreases were shown by blood viscosity, relative viscosity, triglycerides, cholesterol and HbA1c in group III, and by plasma viscosity in group II. alpha 2-Macroglobulins did not change. Fibrinogen was raised in groups I and III. The importance of the improved blood rheological properties is discussed, particularly with respect to reduced erythrocyte flexibility in diabetics.
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Wien. Klin. Wochenschr. · Mar 1985
[Localization of functionally important areas of the regulator protein factor H using monoclonal antibodies].
Four monoclonal antibodies to the control protein of the complement system, factor H, were used to try to localize functionally important domains on the molecule. Attempts to inhibit the interaction of C3b and H in ELISA and agglutination assays by means of these monoclonal antibodies showed that two of them, namely MAH 1 and MAH 2, recognized an epitope in close proximity to the binding site for C3b on H. ⋯ The cofactor function of H with respect to C3b inactivator was inhibited by the same monoclonal antibodies which interfered with the binding of H to C3b. Since MAH 1, MAH 2, MAH 3 and MAH 4 all bind to the same tryptic 38 KD fragment of H, the binding site for C3b on H, as well as the cofactor activity seem to reside on this fragment.
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Wien. Klin. Wochenschr. · Feb 1985
[Biologico-pharmacologically oriented methods of treating depression with special reference to the state of medical practice].
Following a discussion of the diagnostic preconditions that are essential to any treatment of depression, this paper deals with the biologically-based therapies that recommend themselves in psychotherapy. Of chief interest here are the pharmacotherapeutic possibilities and above all the indications of the various antidepressants - many of them new - which are listed together with their German, Austrian and Swiss brand names in Table 8. ⋯ The main types of chronobiological therapy discussed are sleep deprivation and the use of light in the treatment of depression. Finally, there is a brief outline of shock therapy; for non-medical reasons, this no longer plays an important role today, but is nevertheless an extremely effective method of treating depression.