Journal of neurology, neurosurgery, and psychiatry
-
J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Randomized Controlled Trial Clinical TrialA randomised placebo controlled study to assess the effects of cholinergic treatment on muscarinic receptors in Alzheimer's disease.
To determine the effects of cholinergic treatment on the muscarinic receptor in patients with Alzheimer's disease. ⋯ The results suggest that (123)I-QNB uptake is better preserved in Alzheimer's disease patients on cholinergic treatment than on placebo. Cholinergic treatment may play a neuroprotective role. Sequential (123)I-QNB imaging seems to be a powerful tool in monitoring the response of these receptors to disease modifying treatments.
-
J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Randomized Controlled Trial Clinical TrialStroke motor recovery: active neuromuscular stimulation and repetitive practice schedules.
To investigate progress toward motor recovery in patients with chronic hemiparesis (mean time since stroke 3.2 years), comparing different types of practice schedules. ⋯ Upper extremity rehabilitation intervention of active stimulation and blocked practice performed as well as stimulation/random practice. Moreover, these purposeful voluntary movement findings support and extend sensorimotor integration theory to both practice schedules.