Journal of neurology, neurosurgery, and psychiatry
-
J. Neurol. Neurosurg. Psychiatr. · Jan 2004
The epidemiology of multiple sclerosis in Devon: a comparison of the new and old classification criteria.
To determine the prevalence of multiple sclerosis in Devon and compare the new McDonald classification guidelines with the Poser criteria currently used. ⋯ This is first survey to use the new recommended guidelines and compare these criteria with the Poser classification. The difficulties encountered with applying the new criteria in research are highlighted, as are the differences between the new and old criteria. This study reports one of the highest prevalences in the south of the UK, adding support for a north-south divide being a step effect rather than a latitudinal gradient.
-
J. Neurol. Neurosurg. Psychiatr. · Jan 2004
Randomized Controlled Trial Multicenter Study Clinical TrialRopinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries.
To assess the efficacy, safety, and tolerability of ropinirole in the treatment of patients with restless legs syndrome. ⋯ Ropinirole improves restless legs syndrome compared with placebo, with benefits apparent by week 1. It is generally well tolerated.
-
J. Neurol. Neurosurg. Psychiatr. · Jan 2004
Comparative StudyDistinctive cognitive profiles in Alzheimer's disease and subcortical vascular dementia.
There are inconsistencies in published reports regarding the profile of cognitive impairments in vascular dementia, and its differentiation from Alzheimer's disease. ⋯ Subcortical vascular dementia and Alzheimer's disease produce distinctive profiles of cognitive impairment which can act as an adjunct to diagnosis. Many of the neuropsychological deficits thought to characterise Alzheimer's disease are also found in subcortical vascular dementia.