Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Randomized Controlled Trial Clinical TrialClozapine in drug induced psychosis in Parkinson's disease: a randomised, placebo controlled study with open follow up.
To compare the efficacy and safety of clozapine in drug induced psychosis in Parkinson's disease (PD). ⋯ Clozapine at a mean dose lower than 50 mg/day improves drug induced psychosis in PD without significant worsening of motor function, and the effect wears off once the treatment stops.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Letter Case ReportsAcute head drop after cervical hyperflexion injury.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
ReviewSize of the treatment effect on cognition of cholinesterase inhibition in Alzheimer's disease.
Six cholinesterase inhibitors (ChEIs) have been tested in people with Alzheimer's disease, using methods currently required for regulatory approval. The clinical importance of their treatment effects is controversial. ⋯ ChEIs produce small-moderate effect sizes in clinical trials which are reproducible and demonstrate a dose response. Better descriptions of the patterns of treatment response are needed to guide individual patient decisions about the effectiveness of treatment, but group effects are evident and appear large enough to be clinically detectable.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Case ReportsReversible bilateral internuclear ophthalmoplegia associated with FK506.
A 50 year old man developed tonic-clonic seizures while receiving cyclosporin A after orthotopic cardiac transplant. The seizures resolved after cessation of cyclosporin A. ⋯ A temporal association was found between his symptoms and the serum FK506 concentrations. Withdrawal of the intravenous FK506 led to prompt resolution of the bilateral internuclear ophthalmoplegia.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Theoretical analysis of the pathophysiology of syringomyelia associated with adhesive arachnoiditis.
To apply a theoretical model to analyse the derangement of cerebrospinal fluid (CSF) dynamics in syringomyelia associated with adhesive arachnoiditis. ⋯ Blockage of the spinal subarachnoid CSF pathway produces a relative increase in the pressure inside the spinal cord distal to the blockage point. Repetitive formation of this pressure gradient then induces CSF leakage into the spinal parenchyma, leading to the formation of syringomyelia. Using this model, alternative surgical procedures could be suggested that might be effective in treating this disease.