Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Case ReportsReversible bilateral internuclear ophthalmoplegia associated with FK506.
A 50 year old man developed tonic-clonic seizures while receiving cyclosporin A after orthotopic cardiac transplant. The seizures resolved after cessation of cyclosporin A. ⋯ A temporal association was found between his symptoms and the serum FK506 concentrations. Withdrawal of the intravenous FK506 led to prompt resolution of the bilateral internuclear ophthalmoplegia.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Theoretical analysis of the pathophysiology of syringomyelia associated with adhesive arachnoiditis.
To apply a theoretical model to analyse the derangement of cerebrospinal fluid (CSF) dynamics in syringomyelia associated with adhesive arachnoiditis. ⋯ Blockage of the spinal subarachnoid CSF pathway produces a relative increase in the pressure inside the spinal cord distal to the blockage point. Repetitive formation of this pressure gradient then induces CSF leakage into the spinal parenchyma, leading to the formation of syringomyelia. Using this model, alternative surgical procedures could be suggested that might be effective in treating this disease.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Multicenter StudyThe seven minute screen: a neurocognitive screening test highly sensitive to various types of dementia.
The seven minute screen (7MS) is a compilation of the temporal orientation test, enhanced cued recall, clock drawing, and verbal fluency. It has been shown to be useful for detecting Alzheimer's disease in a population of patients with memory complaints. ⋯ The 7MS is a useful screening tool for discriminating patients with dementia from cognitively intact patients. This not only applies to Alzheimer's disease but also to other types of dementia. Specificity with respect to depression was lower for the 7MS than for the MMSE.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Randomized Controlled Trial Clinical TrialUse of short term video EEG in the diagnosis of attack disorders.
Distinguishing epileptic from psychogenic non-epileptic seizures (PNES) often requires video electroencephalography (EEG) recording. Inpatient recording is a limited resource; some evidence suggests that short term video EEG (SVEEG) is useful, but its role in practice has yet to be evaluated. ⋯ SVEEG is a robust and useful diagnostic technique, which complements existing resources.
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J. Neurol. Neurosurg. Psychiatr. · May 2004
Molecular-genetic characterisation of gliomas that recur as same grade or higher grade tumours.
Due to their invasive growth, gliomas usually cannot be removed completely and almost always recur as same grade or higher grade malignancies. ⋯ Gliomas recurring as higher grade lesions might be genetically heterogeneous and accumulate more genetic changes than gliomas recurring as same grade lesions (whether originally low or high grade). Primary glioblastomas from patients for which the recurrence is operated because of prognostically more favourable clinical indices have infrequent EGFR amplification.