Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jun 2004
Case Reports Comparative StudyA dystonic syndrome associated with anti-basal ganglia antibodies.
Anti-basal ganglia antibodies (ABGA) have been associated with movement disorders (usually tics and chorea) and psychiatric disturbance in children. This report describes five adult and adolescent patients (one male, four females; mean age of onset, 16 years (range, 13-35)) who presented subacutely with a clinical syndrome dominated by dystonia and had ABGA binding to antigens of similar molecular weights to those seen in Sydenham's chorea. ⋯ Three patients received immunosuppressive treatment, with three showing a notable reduction in symptoms. It is hypothesised that dystonia in adults or adolescents may be part of the clinical spectrum of the post-infectious syndrome associated with ABGA.
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J. Neurol. Neurosurg. Psychiatr. · Jun 2004
Comparative StudySporadic inclusion body myositis: morphology, regeneration, and cytoskeletal structure of muscle fibres.
To characterise morphological abnormalities in relation to muscle fibre type in sporadic inclusion body myositis (s-IBM). ⋯ There are extensive morphological and morphometric alterations in s-IBM, affecting different muscle fibre types in different ways. The cytoskeletal structure of type I and II muscle fibres remains unaffected in different stages of the disease.
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J. Neurol. Neurosurg. Psychiatr. · Jun 2004
Case ReportsWilson's disease: diagnostic errors and clinical implications.
Therapeutic outcome of Wilson's disease (WD) significantly depends upon its early recognition. However, because of its rarity in community and protean manifestations, the diagnosis and treatment are often delayed. ⋯ Awareness among health professionals about varied presenting features of WD and high index of suspicion may have prognostic implications.
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J. Neurol. Neurosurg. Psychiatr. · Jun 2004
Comparative StudyCorrelation between clinical characteristics and proliferative activity in patients with craniopharyngioma.
The aim of the study was to correlate the Ki-67 and cyclin A labelling index (LI) with clinical characteristics and risk of recurrence of craniopharyngiomas. ⋯ This study confirms the great variability of proliferative activity in craniopharyngiomas. Ki-67 and cyclin A LIs were associated with the presence of a heavy inflammatory reaction and diabetes insipidus, but did not correlate with the long term risk of tumour regrowth.
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J. Neurol. Neurosurg. Psychiatr. · Jun 2004
Letter Comparative Study Clinical TrialPre-treatment with corticosteroids and a single cycle of high dose albendazole for subarachnoidal cysticercosis.