Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jul 2009
Multicenter StudyAssociation between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
Although there is evidence that vitamin D inadequacy may be linked to adverse cognitive outcomes, results from studies on this topic have been inconsistent. The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance in middle-aged and older European men. ⋯ In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2009
Multicenter StudyFunctional and cognitive criteria produce different rates of mild cognitive impairment and conversion to dementia.
To compare rates of mild cognitive impairment (MCI) and rates of progression to dementia using different MCI diagnostic systems. ⋯ Different criteria produce different MCI rates and different conversion rates to dementia. Although a higher percentage of MCI was identified by CDR than NP, a higher percentage of NP MCI progressed to dementia. These findings suggest that the CDR is sensitive to subtle changes in cognition not identified by the NP algorithm but is also sensitive to demographic and clinical factors probably leading to a greater number of false positives. These results suggest that identifying all individuals with CDR scores of 0.5 as Alzheimer's disease is not advisable.