Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Nov 2012
QOLIBRI overall scale: a brief index of health-related quality of life after traumatic brain injury.
The quality of life after brain injury (QOLIBRI) scale is a recently developed instrument that provides a profile of health-related quality of life (HRQoL) in domains typically affected by brain injury. However, for global assessment it is desirable to have a brief summary measure. This study examined a 6-item QOLIBRI overall scale (QOLIBRI-OS), and considered whether it could provide an index of HRQoL after traumatic brain injury (TBI). ⋯ The QOLIBRI-OS assesses a similar construct to the QOLIBRI total score and can be used as a brief index of HRQoL for TBI.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2012
Differentiation of frontotemporal dementia from dementia with Lewy bodies using FP-CIT SPECT.
There is increasing evidence that imaging with [123I]FP-CIT SPECT is helpful in differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) but it is not known how well the scan performs in differentiating DLB from frontotemporal dementia (FTD). ⋯ This study highlights to clinicians that a positive (abnormal) [123I]FP-CIT SPECT scan, even in a patient with an EPMS, does not exclude the diagnosis of FTD and emphasises the importance of a comprehensive clinical evaluation and a detailed cognitive assessment.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2012
Meta AnalysisPost-traumatic amnesia predicts intelligence impairment following traumatic brain injury: a meta-analysis.
Worldwide, millions of patients with traumatic brain injury (TBI) suffer from persistent and disabling intelligence impairment. Post-traumatic amnesia (PTA) duration is a promising predictor of intelligence following TBI. ⋯ PTA duration is a valuable predictor of intelligence impairment following TBI. Results support the routine assessment of PTA duration in clinical settings.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2012
ReviewSocial cognition in neurodegenerative disorders: a systematic review.
Social cognitive neuroscience is the study of the neurobiological systems underlying effective social behaviour. The neural processes supporting effective social interactions in everyday life and the consequences of dysfunction in these processes have been the focus of intense research over the last two decades. ⋯ In addition, accumulating data suggest that detection of early impairment in social cognitive skills may aid in the early diagnosis of cognitive or behavioural impairment in some of these disorders, and may even play a role in the investigation of new therapeutic options. In this review, we outline the basic components of social cognitive processing, provide a systematic review of the literature pertaining to common neurodegenerative conditions, discuss current controversies and make recommendations for future research.