Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Apr 2013
ReviewPatterns and predictors of atypical language representation in epilepsy.
In the majority of the normal population, the left hemisphere is dominant for language. In epilepsy, a higher proportion of 'atypical' language representation is encountered. This can follow one of three patterns: (1) altered interhemispheric representation, where the spectrum of lateralisation is shifted to the right; (2) interhemispheric dissociation of linguistic subfunctions; or (3) intrahemispheric changes in representation. ⋯ Widespread and frequent interictal epileptiform discharges are also associated with atypical language. Atypical language representation is more likely to be present when injury or epilepsy onset occurred at a young age. Thus, a subgroup of patients can be defined in whom atypical language representation is more likely to be found.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2013
Risk of epilepsy after traumatic brain injury: a retrospective population-based cohort study.
To investigate the associated risk of epilepsy after traumatic brain injury (TBI) in a population-based retrospective cohort study. ⋯ The risk of epilepsy after TBI varied by patient gender, age, latent interval and complexity of TBI. Integrated care for early identification and treatment of post-trauma epilepsy were crucial for TBI patients.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2013
Dissociations and similarities in motor intention and motor awareness: the case of anosognosia for hemiplegia and motor neglect.
To confront motor awareness in anosognosia for hemiplegia (AHP), where paralyzed patients deny their motor impairment, and in motor neglect (MN), where non-paralyzed patients behave as if they were paretic. ⋯ Although different in terms of motor intention and motor planning, AHP and MN are both characterised by anosognosia for the motor impairment.
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J. Neurol. Neurosurg. Psychiatr. · Apr 2013
Case ReportsInfrequent SCN9A mutations in congenital insensitivity to pain and erythromelalgia.
Mutations in SCN9A have been reported in (1) congenital insensitivity to pain (CIP); (2) primary erythromelalgia; (3) paroxysmal extreme pain disorder; (4) febrile seizures and recently (5) small fibre sensory neuropathy. We sought to investigate for SCN9A mutations in a clinically well-characterised cohort of patients with CIP and erythromelalgia. ⋯ Two novel SCN9A mutations were identified, but frequently polymorphism variants are found which may provide susceptibility factors in pain modulation. CIP and erythromelalgia are defined as genetically heterogeneous, and some SCN9A variants previously considered causal may only be modifying factors.