Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Common variants on 9p21.3 are associated with brain arteriovenous malformations with accompanying arterial aneurysms.
To investigate whether previously reported 9p21.3 single nucleotide polymorphisms (SNPs) are associated with risk of brain arteriovenous malformations (BAVM), which often have accompanying arterial aneurysms. Common variants in the 9p21.3 locus have been reported to be associated with multiple cardiovascular phenotypes, including coronary artery disease and intracranial aneurysms (rs10757278 and rs1333040). ⋯ Common 9p21.3 variants showed similar effect sizes for association with BAVM as previously reported for aneurysmal disease. The association with BAVM appears to be explained by known associations with aneurysms, suggesting that BAVM-associated aneurysms share similar vascular pathology mechanisms with other aneurysm types.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Mortality and morbidity 15 years after hospital admission with mild head injury: a prospective case-controlled population study.
To investigate mortality rate in a population of adults admitted to hospital with mild head injury (MHI) 15 years later. ⋯ Adults hospitalised with MHI had greater risk of death in the following 15 years than matched controls. The extent to which lifestyle and potential chronic changes in neuropathology explain these findings is unclear. Lifestyle factors do contribute to risk of death after MHI and this finding has implications for lifestyle management interventions.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Risk factors for congenital hydrocephalus: a nationwide, register-based, cohort study.
To investigate the associations between isolated congenital hydrocephalus (CHC) and maternal characteristics, maternal medical diseases, and medicine intake during pregnancy as well as birth characteristics of the child in a retrospective, register-based, nationwide cohort study. Furthermore, to identify the risk factors unique for isolated CHC as compared to syndromic CHC. ⋯ The higher risk for isolated CHC in first-born children as well as behavioural aspects and comorbidities associated with maternal use of antidepressants, should be the targets for future research. Potential biological pathways by which antidepressants may cause hydrocephalus remain to be elucidated.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort.
Results conflict concerning the relevance of APOE alleles on the development of dementia with Lewy bodies (DLB), though they are well established in connection with Alzheimer's disease (AD). The role of APOE alleles in a Norwegian cohort of patients with DLB was therefore examined compared with patients with AD and healthy control individuals. ⋯ The results indicate that APOE ε2, a protective factor in AD, has a clear beneficial effect on the development of DLB also.