Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Randomized Controlled Trial Multicenter StudyLong-term impact of interferon beta-1b in patients with CIS: 8-year follow-up of BENEFIT.
To examine the long-term impact of early treatment initiation of interferon beta-1b (IFNB1b, Betaferon/Betaseron) in patients with a first event suggestive of multiple sclerosis (MS). ⋯ These 8-year results provide further evidence supporting early initiation of treatment with IFNB1b in patients with a first event suggestive of MS.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Randomized Controlled TrialOral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial.
This double-blind, placebo-controlled, dose-finding phase IIb study evaluated the efficacy and safety of ponesimod, an oral selective S1P1 receptor modulator, for the treatment of patients with relapsing-remitting multiple sclerosis (RRMS). ⋯ Once-daily treatment with ponesimod 10, 20 or 40 mg significantly reduced the number of new T1 Gd+ lesions and showed a beneficial effect on clinical endpoints. Ponesimod was generally well tolerated, and further investigation of ponesimod for the treatment of RRMS is under consideration.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Randomized Controlled TrialImmediate effect of spinal magnetic stimulation on camptocormia in Parkinson's disease.
Spinal cord stimulation is a potential therapeutic option for the treatment of Parkinson's disease (PD)-associated symptoms. Repetitive trans-spinal magnetic stimulation (rTSMS) is a non-invasive and safe alternative for stimulation of spinal pathways that has not been studied for therapeutic efficacy in PD. We assessed the benefits of rTSMS on camptocormia, an often treatment-resistant postural abnormality observed in PD patients. ⋯ UMIN Clinical Trials Registry: UMIN000011495.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Randomized Controlled TrialDegree of blood pressure reduction and recurrent stroke: the PROGRESS trial.
There is ongoing controversy regarding a 'J-curve' phenomenon such that low and high blood pressure (BP) levels are associated with increased risks of recurrent stroke. We aimed to determine whether large treatment-related BP reductions are associated with increased risks of recurrent stroke. ⋯ The present analysis provided no evidence of an increase in recurrent stroke associated with larger reductions in SBP produced by treatment among patients with cerebrovascular disease.