Journal of neurology, neurosurgery, and psychiatry

The most recent articles from: J. Neurol. Neurosurg. Psychiatr. February 2019

J. Neurol. Neurosurg. Psychiatr. · Feb 2019

Meta Analysis

Genetic risk factors for modulation of age at onset in Machado-Joseph disease/spinocerebellar ataxia type 3: a systematic review and meta-analysis.

To perform a systematic review and meta-analysis of genetic risk factors for age at onset (AO) in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). ⋯ Current evidence supports genetic modulation of AO in SCA3/MJD by CAGexp, ATXN2 and family-specific and population-specific factors. Future studies should take these into account in the search for new genetic modifiers of AO, which could be of therapeutic relevance.

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