Journal of neurology, neurosurgery, and psychiatry
-
J. Neurol. Neurosurg. Psychiatr. · Jan 2025
Randomized Controlled TrialRandomised controlled trial of intermittent calorie restriction in people with multiple sclerosis.
Calorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) via multiple mechanisms. These include decreased leptin, a proinflammatory adipokine, but mechanistic studies in humans are lacking. Tests of daily and intermittent CR (iCR) in people with MS (pwMS) showed improvements in fatigue and well-being measures. This trial studied the effects of 12-week iCR on metabolic, immunological, and clinical outcomes in pwMS. ⋯ iCR has the potential to benefit metabolic and immunologic profiles and is safe and feasible in pwMS.
-
J. Neurol. Neurosurg. Psychiatr. · Jan 2025
Randomized Controlled Trial Multicenter StudyMeasurement properties of the Inclusion Body Myositis Functional Rating Scale.
To evaluate the validity, reliability, responsiveness and meaningful change threshold of the Inclusion Body Myositis (IBM) Functional Rating Scale (FRS). ⋯ When administered by trained raters, the IBMFRS is a reliable, valid and responsive tool that can be used to evaluate the impact of IBM and its treatment on physical function, with a 2-point reduction representing meaningful decline.