Lancet
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Multicenter Study Meta Analysis Comparative Study
Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study.
Whether people living with HIV who have not received antiretroviral therapy (ART) and have high CD4 cell counts have higher mortality than the general population is unknown. We aimed to examine this by analysis of pooled data from industrialised countries. ⋯ European Commission, FP6. European AIDS Treatment Network (NEAT). Project number LSHP-CT-2006-037570.
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Comment Multicenter Study Meta Analysis
Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests that genetic factors could also play a part. We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency. ⋯ Full funding sources listed at end of paper (see Acknowledgments).