JAMA : the journal of the American Medical Association
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Multicenter Study
Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant.
Neonatal herpes most commonly results from fetal exposure to infected maternal genital secretions at the time of delivery. The risk of transmission from mother to infant as it relates to maternal herpes simplex virus (HSV) serologic status and exposure to HSV in the maternal genital tract at the time of labor has not been quantified. Furthermore, no data exist on whether cesarean delivery, the standard of care for women with genital herpes lesions at the time of delivery, reduces HSV transmission. ⋯ Neonatal HSV infection rates can be reduced by preventing maternal acquisition of genital HSV-1 and HSV-2 infection near term. It can also be reduced by cesarean delivery and limiting the use of invasive monitors among women shedding HSV at the time of labor.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial.
Sexual dysfunction is a common adverse effect of antidepressants that frequently results in treatment noncompliance. ⋯ In our study, sildenafil effectively improved erectile function and other aspects of sexual function in men with sexual dysfunction associated with the use of SRI antidepressants. These improvements may allow patients to maintain adherence with effective antidepressant treatment.