JAMA : the journal of the American Medical Association
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Randomized Controlled Trial Multicenter Study
Effects of initiating insulin and metformin on glycemic control and inflammatory biomarkers among patients with type 2 diabetes: the LANCET randomized trial.
As diabetes is in part an inflammatory condition, the initiation of insulin and/or metformin may beneficially reduce levels of inflammatory biomarkers such as high-sensitivity C-reactive protein (hsCRP). ⋯ In patients with recent-onset type 2 diabetes, treatment with insulin or metformin compared with placebo did not reduce inflammatory biomarker levels despite improving glucose control.
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Randomized Controlled Trial Multicenter Study Comparative Study
Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial.
In previous smaller trials, a procalcitonin (PCT) algorithm reduced antibiotic use in patients with lower respiratory tract infections (LRTIs). ⋯ In patients with LRTIs, a strategy of PCT guidance compared with standard guidelines resulted in similar rates of adverse outcomes, as well as lower rates of antibiotic exposure and antibiotic-associated adverse effects.
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Randomized Controlled Trial Multicenter Study
Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trial.
Kidney graft function after transplantation can be improved through pharmacological donor pretreatment to limit organ injury from cold preservation. ⋯ Donor pretreatment with low-dose dopamine reduces the need for dialysis after kidney transplantation.
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Randomized Controlled Trial Multicenter Study Comparative Study
Immediate vs delayed intervention for acute coronary syndromes: a randomized clinical trial.
International guidelines recommend an early invasive strategy for patients with high-risk acute coronary syndromes without ST-segment elevation, but the optimal timing of intervention is uncertain. ⋯ In patients with acute coronary syndromes without ST-segment elevation, a strategy of immediate intervention compared with a strategy of intervention deferred to the next working day (mean, 21 hours) did not result in a difference in myocardial infarction as defined by peak troponin level.