Journal of neurosurgery
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Journal of neurosurgery · Jun 2003
Randomized Controlled Trial Clinical TrialEffect of the local anesthetic agent bupivacaine prior to application of the skull-pin holder for craniotomies.
The authors conducted a double-blind prospective randomized study to determine whether infiltration of Mayfield skull-pin sites with 0.5% bupivacaine, compared with placebo, would prevent hemodynamic stimulation, thus allowing for a reduction in the quantity of anesthetic agents required. ⋯ The local administration of bupivacaine for anesthetic purposes before skull-pin application may prevent potentially hazardous hemodynamic stimulation.