Neuroscience
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Biological (BA) and chronological (CA) age may or may not fit. The available evidence reveals remarkable individual differences in the overlap/mismatch between BA and CA. Increased mismatch can be interpreted as delayed (BA/CA < 1) or accelerated biological aging (BA/CA > 1). ⋯ Next, brain age was computed at the individual level for two distinguishable neocortical features (thickness and surface area) according to models trained in an independent large-scale sample of 2377 individuals. Results revealed a stronger pattern of accelerated brain aging in HCA compared to ACA individuals for thickness, while the opposite pattern was suggested for surface area. The findings align well with the greater relevance of individual differences in cortical surface area for enhancing our understanding of cognitive differences at the brain level.
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It is known that besides synaptic inhibition, there is a persistent component of inhibitory drive mediated by tonic currents which is believed to mediate majority of the total inhibitory charge in hippocampal neurons. Tonic currents, depending on cell types, can be mediated by a variety of GABAA receptor (GABAAR) subtypes but in pyramidal neurons, α5-subunit containing receptors were found to be predominant. Importantly, α5-GABAARs were implicated in both inhibitory and excitatory synaptic plasticity as well as in a variety of cognitive tasks. ⋯ On the contrary, the iLTP induction did not affect the tonic current potentiated by THIP, indicating that the pool of δ subunit-containing GABAARs receptors remains unaffected. We conclude that the α5-GABAARs-dependent plasticity of tonic inhibition is a novel dimension of the neuroplasticity of the inhibitory drive in the hippocampal principal neurons. Overall, α5-containing GABAARs emerge as key players in a variety of plasticity mechanisms operating over a large span of time and spatial scales.
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Stimulation with a low frequency electromagnetic field (LF-EMF) has proven to represent a powerful method for the suppression of seizures, as demonstrated in select clinical and laboratory studies. However, the mechanism by which LF-EMF suppresses seizures remains unclear. The purpose of the present study was to explore the modulatory effect of LF-EMF on epileptiform discharges (EDs) using rat hippocampal slices and investigate the underlying mechanisms that mediate these effects. ⋯ The addition of BIC resulted in EDs that had previously been inhibited by magnetic fields, reappearing. Low-frequency magnetic stimulation was able to inhibit the conversion from interictal discharges (IIDs) or preictal discharges (PIDs) to IDs. This suppression was attributed to the modulation of GABAA receptor activity.
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The slow afterhyperpolarizing potential (sAHP) can silence a neuron for hundreds of milliseconds. Thereby, the sAHP determines the discharge behavior of many types of neurons. In dentate granule cells (DGCs), serving as a filter into the hippocampal network, mostly tonic or adapting discharge properties have been described. ⋯ Application of 100 µM nickel after XE991 and tolbutamide detected a third conductance contributing to burst-like firing and the sAHP, most likely mediated by T-type calcium channels. Lastly, medial perforant path-dentate gyrus long-term potentiation was amplified by XE991 and tolbutamide. In conclusion, the sAHP shapes intrinsic burst-like firing which, under physiological circumstances, could be controlled via cholinergic afferents and ATP metabolism.
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Research in both bottom-up and top-down attention has shown that behavioural performance is related to brain oscillations at the time of stimulus presentation: the angle of the theta phase in bottom-up attention and the inhibition of alpha oscillations in top-down attention. However, whether the conditions most favourable for bottom-up attention change with the addition of top-down cues is unclear. To explore the characteristics of favourable oscillations during bottom-up processing, in experiment 1, 36 participants completed a selective attention task (visual search) without cues. ⋯ However, some characteristics that were associated with better performance, including theta power and low beta power, were changed after the addition of different cues. In addition, there were some new characteristics related to improved performance under temporal and spatial anticipation. These results suggest that top-down attention implements a more energy-efficient strategy to process information, optimizing the process of bottom-up attention.