Spine
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Randomized Controlled Trial Multicenter Study
Efficacy and safety of a novel moldable, resorbable, and degradable sealant of bone surfaces for hemostasis after bone graft harvesting from the iliac crest.
A prospective, controlled, open, randomized multicenter study. ⋯ Bone Seal is an effective and safe hemostatic material for sealing bleeding bone surfaces after iliac crest bone graft harvesting. By virtue of its hemostatic efficacy, Bone Seal is preventive for wound healing disorders.
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A retrospective longitudinal study of 434 consecutive pediatric patients who underwent surgical correction of scoliosis, while being monitored for positional brachial plexopathy. ⋯ Avoidance of neurologic injury to the brachial plexus during scoliosis surgery is possible by early detection with ulnar nerve SSEP monitoring.
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A systematic review of the medical literature regarding current intradiscal therapeutic methods. ⋯ Low back pain is an extremely common and potentially debilitating problem. Adding biophysical methods to well-tested biomechanical and newly investigated biomolecular solutions allows for multiple avenues of therapeutic interventions. With future clinical and basic science studies regarding intradiscal therapies forthcoming, we may soon alter our current treatment algorithms for the management of discogenic back pain.
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Review
Cost-effectiveness of single-level anterior cervical discectomy and fusion for cervical spondylosis.
Cost-effectiveness analysis with retrospective cost analysis and literature review. ⋯ ACDF with allograft offers a benefit relative to ACDF with autograft at a cost of 496 dollars per QALY. ACDFP has a benefit relative to ACDF with allograft at an approximate cost of 32,560 dollars per QALY. CEA provides a method for comparing the benefits and risks of these three procedures. Further research needs to be performed regarding these procedures, particularly examining the postoperative recovery period.
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Randomized Controlled Trial
The role of amicar in decreasing perioperative blood loss in idiopathic scoliosis.
Four separate studies on the role of Amicar in decreasing perioperative blood loss in idiopathic scoliosis. ⋯ Amicar appears highly effective in decreasing perioperative blood loss. This results in less autologous blood donation, blood transfusion, costs, and complications. Its mechanism of action is uncertain but may be related to increased fibrinogen secretion.