Spine
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Review
Safety and effectiveness of bone allografts in anterior cervical discectomy and fusion surgery.
Systematic review. ⋯ ACDF with allograft, ACDF with autograft, ACDF with cage, and cervical disc arthroplasty show similar improvements in pain, function, and quality of life with correspondingly low adverse event rates. All ACDF procedures result in high fusion rates.
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Prospective cohort study. ⋯ In this sample of workers' compensation recipients, the high procedure cost of SCS was not counterbalanced by lower costs of subsequent care, and SCS was not cost-effective. The benefits and potential cost savings reported in RCTs may not be replicated in workers' compensation patients treated in community settings.
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Cost-effectiveness analysis of a randomized plus observational cohort trial. ⋯ Comparative effectiveness evidence for clearly defined diagnostic groups from Spine Patient Outcomes Research Trial shows good value for surgery compared with nonoperative care over 4 years.
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Controlled Clinical Trial
Gastroesophageal reflux after anterior cervical surgery: a controlled, prospective analysis.
Prospective controlled clinical study. ⋯ Compared to the lumbar control group, patients in the cervical group had increased incidence, and severity of GERD-like symptoms in the early postoperative period.
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Immunohistochemical analysis of type IX collagen in disc tissue from spinal fusion patients. ⋯ During growth and maturation of the disc, collagen IX is presumably removed completely during matrix remodeling so that the protein is absent from normal adult annulus and nucleus but can reappear at sites of degeneration presumably as part of a repair response to mechanical injury.