Intensive care medicine
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Intensive care medicine · Jul 2019
ReviewMolecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases.
Molecular targeted therapy increased overall and disease-free survival in a wide range of malignancies. Although generally well tolerated compared to chemotherapy, molecular targeted therapy may be associated with adverse events requiring ICU admission. Informing clinicians about clinical features of these toxic events might maintain awareness and favor early recognition, prompt diagnosis and treatment. ⋯ Based on the vast number of treated patients, only 253 cases of molecular therapy-related severe toxicity are reported in cancer patients. Symptoms and biomarkers that depict these events need to be better identified as to allow appropriate reporting and improving dose and schedule of the treatment adapted to each patient.
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Intensive care medicine · Jul 2019
Key mechanisms by which post-ICU activities can improve in-ICU care: results of the international THRIVE collaboratives.
To identify the key mechanisms that clinicians perceive improve care in the intensive care unit (ICU), as a result of their involvement in post-ICU programs. ⋯ The follow-up of patients and families in post-ICU care settings is perceived to improve care within the ICU via five key mechanisms. Further research is required in this novel area.