Médecine et maladies infectieuses
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Multicenter Study Observational Study
Extended-spectrum β-lactamase-producing Enterobacteriaceae, national study of antimicrobial treatment for pediatric urinary tract infection.
To evaluate clinical practices for ESBL-producing urinary tract infection (UTI) in France. ⋯ Antimicrobial treatment for ESBL-producing UTI greatly varies, and carbapenems are excessively prescribed. Specific guidelines for ESBL infections are required.
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Multicenter Study
Community-acquired pneumonia and positive urinary antigen tests: Factors associated with targeted antibiotic therapy.
The use of rapid microbiological tests is supported by antimicrobial stewardship policies. Targeted antibiotic therapy (TAT) for community-acquired pneumonia (CAP) with positive urinary antigen test (UAT) has been associated with a favorable impact on outcome. We aimed to determine the factors associated with TAT prescription. ⋯ TAT in CAP with positive UAT was related to the hospitals as well as to patient characteristics.
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Multicenter Study
Prosthetic joint infection: A pluridisciplinary multi-center audit bridging quality of care and outcome.
Care to patients with prosthetic joint infections (PJI) is provided after pluridisciplinary collaboration, in particular for complex presentations. Therefore, to carry out an audit in PJI justifies using pluridisciplinary criteria. We report an audit for hip or knee PJI, with emphasis on care homogeneity, length of hospital stay (LOS) and mortality. ⋯ Care to patients with PJI was heterogeneous, our quality criteria being correlated to the outcome.
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Multicenter Study Comparative Study Observational Study
Prevalence and impact on quality of life of post-herpetic neuralgia in French medical centers specialized in chronic pain management: the ZOCAD study.
(1) We had for aim to determine the rate of patients consulting for post-herpetic neuralgia (PHN) in centers specialized in the management of chronic pain, (2) to assess the burden of PHN, (3) to compare the impact of PHN between new (newly consulting for PHN) and known (already treated by pain specialists) patients. ⋯ PHN is a frequent cause of visit in French medical centers specialized in chronic pain management long after the rash has disappeared, and a reason for treatment with drugs that should be prescribed cautiously in elderly patients.
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Randomized Controlled Trial Multicenter Study Comparative Study
The ZEPHyR study: a randomized comparison of linezolid and vancomycin for MRSA pneumonia.
Methicillin-resistant Staphylococcus aureus (MRSA) accounts for 10-40% of hospital-acquired pneumonia, and even more in intensive care units. The current guidelines for the treatment of MRSA nosocomial pneumonia include vancomycin and linezolid. The authors of 2 prospective randomized trials comparing vancomycin and linezolid in nosocomial pneumonia had concluded to the non-inferiority of linezolid. A slight superiority of linezolid was observed in the MRSA pneumonia subgroup, in terms of clinical success and survival, but no definite conclusion could be drawn. ⋯ LNZ was superior to vancomycin for the treatment of MRSA nosocomial pneumonia.