The American journal of emergency medicine
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Randomized Controlled Trial Clinical Trial
Low-dose naloxone does not improve morphine-induced nausea, vomiting, or pruritus.
We tested the hypothesis that low-dose naloxone delivered with intravenous (IV) bolus morphine to emergency department patients in pain would reduce nausea. ⋯ Addition of 0.25 microg/kg naloxone to bolus morphine does not improve nausea, pruritus, vomiting, or reduce use of rescue antiemetics when administered to emergency department patients in pain.