The American journal of emergency medicine
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Randomized Controlled Trial
A randomized controlled trial of capnography during sedation in a pediatric emergency setting.
Data suggest that capnography is a more sensitive measure of ventilation than standard modalities and detects respiratory depression before hypoxemia occurs. We sought to determine if adding capnography to standard monitoring during sedation of children increased the frequency of interventions for hypoventilation, and whether these interventions would decrease the frequency of oxygen desaturations. ⋯ Hypoventilation is common during sedation of pediatric emergency department patients. This can be difficult to detect by current monitoring methods other than capnography. Providers with access to capnography provided fewer but more timely interventions for hypoventilation. This led to fewer episodes of hypoventilation and of oxygen desaturation.
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Randomized Controlled Trial Multicenter Study
A randomized trial of benralizumab, an antiinterleukin 5 receptor α monoclonal antibody, after acute asthma.
Patients with frequent asthma exacerbations resulting in emergency department (ED) visits are at increased risk for future exacerbations. We examined the ability of 1 dose of benralizumab, an investigational antiinterleukin 5 receptor α monoclonal antibody, to reduce recurrence after acute asthma exacerbations. ⋯ When added to usual care, 1 dose of benralizumab reduced the rate and severity of exacerbations experienced over 12 weeks by subjects who presented to the ED with acute asthma.
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Letter Randomized Controlled Trial Comparative Study
Quality of chest compression: comparison CardioPump cardiopulmonary resuscitation with standard basic life support in a single-rescuer scenario. A manikin study.