The American journal of emergency medicine
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Meta Analysis
Premorbid angiotensin converting enzyme inhibitors or angiotensin II receptor blockers in patients with sepsis.
The aim of this study was to conduct a systematic review and meta-analysis to investigate the effect of the premorbid use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (ACEI/ARB) on short-term mortality in patients with sepsis. ⋯ In this meta-analysis, the premorbid ACEI/ARB was associated with significantly lower short-term mortality in patients with sepsis despite the significantly higher risk of AKI.
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Review Meta Analysis
A year ReviewED: Top emergency medicine pharmacotherapy articles of 2021.
This article highlights the most relevant emergency medicine (EM) pharmacotherapy publications indexed in 2021. A modified Delphi approach was utilized for selected journals to identify the most impactful EM pharmacotherapy studies via the GRADE system. ⋯ Articles included in this review highlight acute agitation management, acute appendicitis treatment, sexually transmitted infection updates, optimizing sepsis management and treatment, updates for the ideal thrombolytic agent in acute ischemic stroke and endovascular therapy candidates, indications for tranexamic acid, calicium for out of hospital cardiac arrest, optimial inotrope for cardiogenic shock, awareness during rapid sequence intubation paralysis, comparison of propofol or dexmedetomidine for sedation, treatment of cannabis hyperemsis syndrome, and prophylactic use of diphenhydramine to reduce neuroleptic side effects. Selected articles are summarized to include design, results, limitations, conclusions and impact.
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Review Meta Analysis
Delirium prevalence in geriatric emergency department patients: A systematic review and meta-analysis.
In the emergency department, delirium associated with serious adverse outcomes is common in geriatric patients. We performed a meta-analysis and estimated the prevalence of delirium and its related factors among geriatric emergency department patients. ⋯ In the emergency department, delirium is common in geriatric patients. We should pay specific attention to delirium screening, prevention, and treatment in geriatric patients. Overall appropriate interventions should be utilized to reduce the occurrence of delirium and the adverse outcomes.
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Comment Letter Meta Analysis
Comment on "Effectiveness and safety of tranexamic acid in pediatric trauma: A systematic review and meta-analysis".
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Comment Letter Meta Analysis
Tranexamic acid and Gastrointestinal bleed: Effect of the HALT-IT trial on current meta-analysis.