The American journal of emergency medicine
The most recent articles from:
Am J Emerg Med
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Comparative Study
Cytidine diphosphate choline improves the outcome of cardiac arrest vs epinephrine in rat model.
Cytidine diphosphate choline (CDP-choline) is a cholinergic agent that can both stimulate the cholinergic pathway and increase blood pressure. We aimed to investigate the effects of CDP-choline on the outcome of cardiac arrest in comparison with epinephrine. ⋯ When administered during resuscitation, CDP-choline increased the rate of return of spontaneous circulation similarly to epinephrine. In addition, it did not increase the severity of myocardial injury and postresuscitation myocardial dysfunction, whereas epinephrine appeared to be harmful.