Anaesthesia and intensive care
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Anaesth Intensive Care · Jun 1999
Randomized Controlled Trial Multicenter Study Clinical TrialSafety and efficacy of target controlled infusion (Diprifusor) vs manually controlled infusion of propofol for anaesthesia.
In this multi-centre, randomized trial, we compared the safety and efficacy of Diprifusor TCI with manually controlled infusion (MCI) of propofol for anaesthesia. With approval, 123 adult male and female patients were studied. Firstly, each investigator anaesthetized five patients to familiarize themselves with Diprifusor TCI. ⋯ There were statistically but not clinically significant differences in mean arterial blood pressure and heart rate. Quality of anaesthesia and ease of control of anaesthesia were similar. We conclude that Diprifusor TCI and MCI are similar in terms of safety and efficacy.