Pediatric pulmonology
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Pediatric pulmonology · Sep 2018
Randomized Controlled Trial Multicenter StudyNasal high-frequency oscillatory ventilation and CO2 removal: A randomized controlled crossover trial.
To compare short-term application of nasal high-frequency oscillatory ventilation (nHFOV) with nasal continuous positive airway pressure (nCPAP). ⋯ nHFOV delivered through nasal prongs is more effective than nCPAP in improving the elimination of CO2 .
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In pediatric patients with chronic cough, respiratory culture techniques commonly yield negative results. Studies using culture-independent methods have found a high relative abundance of oral microbes in the lower airways, suggesting that the topographical continuity, and dynamics of the intraluminal contents of the aerodigestive system likely influence the lower airway microbiota. We hypothesize that in subjects with chronic cough, clinical diagnosis will correlate with distinct microbial signatures detected using culture-independent methods.