The Journal of international medical research
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Randomized Controlled Trial
Optimal dose of dexmedetomidine for attenuating cardiovascular response during emergence in patients undergoing total laparoscopic hysterectomy.
To investigate the optimal dose of dexmedetomidine for attenuating the haemodynamic response during emergence from anaesthesia. ⋯ Intravenous infusion of 0.5 µg/kg dexmedetomidine 30 min before the end of surgery attenuated the haemodynamic responses during emergence without prolonging the extubation time. Dexmedetomidine doses higher than 0.5 µg/kg did not exert additional positive effects on cardiovascular responses, but did significantly prolong the extubation time.