Journal of pain and symptom management
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J Pain Symptom Manage · Feb 2011
Randomized Controlled TrialThe association of depression and preferences for life-sustaining treatments in veterans with chronic obstructive pulmonary disease.
Depressive symptoms are common among patients with chronic obstructive pulmonary disease (COPD) and may modify patients' preferences for life-sustaining therapy. Examining the relationship between patient preferences for life-sustaining treatments and depressive symptoms is important for clinicians engaging in end-of-life care discussions. ⋯ Depressive history and active symptoms among veterans with severe COPD were not associated with their decisions for life-sustaining treatments. Clinicians caring for patients with COPD should understand the importance of assessing and treating patients with depressive symptoms, yet recognize that depressive symptoms may not be predictive of a patient declining life-sustaining treatments.
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J Pain Symptom Manage · Feb 2011
Randomized Controlled Trial Multicenter StudyConsistency of efficacy, patient acceptability, and nasal tolerability of fentanyl pectin nasal spray compared with immediate-release morphine sulfate in breakthrough cancer pain.
We recently reported that fentanyl pectin nasal spray (FPNS) provides superior pain relief from breakthrough cancer pain (BTCP) compared with immediate-release morphine sulfate (IRMS), with significant effects by five minutes and clinically meaningful pain relief from 10 minutes postdose. ⋯ This study demonstrates that FPNS is efficacious, well accepted, and well tolerated by patients with BTCP.