Journal of pain and symptom management
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J Pain Symptom Manage · Mar 2017
Randomized Controlled Trial Multicenter StudyFatigue during and after breast cancer therapy - A prospective study.
Chronic fatigue (CF) in breast cancer (BC) survivors is multifactorial and may be caused by immune activation triggered by BC or its treatment. In the Neoadjuvant Avastin in Breast Cancer study, BC patients received neoadjuvant chemotherapy (FEC100→taxane) ± bevacizumab, a monoclonal antibody with fatigue as a potential side effect. ⋯ Neither bevacizumab treatment nor low-grade systemic inflammation as measured by CRP was associated with the increased fatigue levels and raised prevalence of CF, observed during and after BC therapy. Increased fatigue levels at baseline and psychological distress at T3 were associated with CF at T3.
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J Pain Symptom Manage · Mar 2017
Association between Multi-Frequency Phase Angle and Survival in Patients with Advanced Cancer.
The ability to predict survival accurately has implications in clinical decision making. ⋯ Phase angle represents a novel objective prognostic factor in outpatient palliative cancer care setting, regardless of frequency and body sides.
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J Pain Symptom Manage · Mar 2017
ReviewTopical Treatment of Peripheral Neuropathic Pain: Applying the Evidence.
Patients with peripheral neuropathic pain (NP) may only achieve partial pain relief with currently recommended first-line oral treatments, which are also associated with systemic adverse events. Topical treatments are currently considered second- or third-line options, but a recent pharmacologic treatment algorithm has called for broader first-line use of these agents. This has highlighted a need to communicate the benefits associated with topical agents, in particular around the efficacy, targeted local action, and limited systemic availability resulting in minimal systemic adverse events and drug-drug interactions. ⋯ First-line use of topical agents may be of particular benefit in patients where the safety and tolerability of oral therapy is a concern.
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J Pain Symptom Manage · Mar 2017
A cross-sectional study on the symptom burden of patients with spinal tumor: validation of the Chinese version of the MD Anderson Symptom Inventory - Spine Tumor Module (MDASI-SP).
Tumors involving the spine are associated with unique symptoms affecting both patient survival and health-related quality of life. Currently, there is no disease-specific instrument in Chinese to assess the symptom burden of these patients. ⋯ MDASI-SP-C demonstrated satisfactory psychometric properties and could be used to better assess the symptom burden of Chinese-speaking patients with spine tumors for improved management of their medical needs.
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