Journal of critical care
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Journal of critical care · Aug 2019
ReviewMajor publications in critical care pharmacotherapy literature in 2018.
To summarize selected original critical care pharmacotherapy research published in 2018. ⋯ This clinical review and expert commentary of impactful critical care pharmacotherapy publications in 2018 provides perspectives and insights for the critical care practitioner.
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Journal of critical care · Aug 2019
ReviewMajor publications in critical care pharmacotherapy literature in 2018.
To summarize selected original critical care pharmacotherapy research published in 2018. ⋯ This clinical review and expert commentary of impactful critical care pharmacotherapy publications in 2018 provides perspectives and insights for the critical care practitioner.
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Journal of critical care · Jun 2019
Review Case ReportsSevere acute respiratory distress syndrome (ARDS) induced by human adenovirus B21: Report on 2 cases and literature review.
Severe pneumonia and ARDS caused by human adenovirus B21 infections (HAdV-B21) is a rare, but a devastating disease with rapid progression to multiorgan failure and death. However, only a few cases were reported so far. Infections appear associated with increased disease severity and higher mortality in infected critically ill patients. ⋯ In conclusion, data on HAdV-B21 infections causing severe pneumonia or ARDS are scarce. Controlled clinical trials on the therapy of adenovirus pneumonia are non existent and thus there is no established therapy so far. ICU physicians should be aware of this potentially devastating disease and further studies are needed.
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Journal of critical care · Jun 2019
Review Meta AnalysisWorldwide variation in Pseudomonas associated ventilator associated pneumonia. A meta-regression.
The objective here is to define the extent and possible reasons for geographic variation in Pseudomonas aeruginosa associated with Ventilator Associated Pneumonia (VAP). ⋯ Pseudomonas associated VAP incidence among reports from six geographic regions worldwide varies by less than twofold with some decline by year of publication. Trauma ICU admission is a significant factor underlying variations in incidence of VAP overall but not Pseudomonas associated VAP.
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Journal of critical care · Jun 2019
Sodium bicarbonate therapy for critically ill patients with metabolic acidosis: A scoping and a systematic review.
We aimed to assess the biochemical and physiological effects, clinical efficacy, and safety, of intravenous NaHCO3 therapy in critically ill patients with acute metabolic acidosis. ⋯ Given the lack of data on the effects of intravenous NaHCO3 therapy to support its clinical use and the frequency of bicarbonate therapy, a program of investigation appears justified.