Journal of critical care
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Journal of critical care · Dec 2010
Review Meta AnalysisThe effect of statins on mortality from severe infections and sepsis: a systematic review and meta-analysis.
The aim of this study was to systematically review the literature on the effect of statins on mortality in patients with infection and/or sepsis. ⋯ This meta-analysis demonstrated a protective effect for statins in patients with sepsis and/or other infections compared to placebo for various infection-related outcomes. However, our results are limited by the cohort design of the selected studies and the degree of heterogeneity among them, and as a result, further randomized trials are needed to validate the use of statins for sepsis and/or other infections.