Journal of critical care
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Journal of critical care · Dec 2010
Review Comparative StudyIntensive- vs less-intensive-dose continuous renal replacement therapy for the intensive care unit-related acute kidney injury: a meta-analysis and systematic review.
The aim of the study is to summarize the effect of intensive-dose continuous renal replacement therapy (CRRT) on the mortality and other clinical outcomes. ⋯ This meta-analysis provides additional evidence that the higher dose of CRRT is not sufficient in reducing the mortality in critically ill patients with acute renal failure.
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Journal of critical care · Dec 2010
Review Meta AnalysisThe effect of statins on mortality from severe infections and sepsis: a systematic review and meta-analysis.
The aim of this study was to systematically review the literature on the effect of statins on mortality in patients with infection and/or sepsis. ⋯ This meta-analysis demonstrated a protective effect for statins in patients with sepsis and/or other infections compared to placebo for various infection-related outcomes. However, our results are limited by the cohort design of the selected studies and the degree of heterogeneity among them, and as a result, further randomized trials are needed to validate the use of statins for sepsis and/or other infections.