Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Randomized Controlled Trial Clinical Trial
Intraoperative high dose fentanyl induces postoperative fentanyl tolerance.
In a randomized, double-blind clinical trial, we compared the postoperative analgesic effect and dose consumption of fentanyl after intraoperative high dose and low dose fentanyl administration. ⋯ Our results suggest that acute fentanyl tolerance develops after administration of high dose fentanyl during surgery and, consequently, results in a higher postoperative pain intensity and greater fentanyl consumption.
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Randomized Controlled Trial Comparative Study Clinical Trial
Intraarticular fentanyl compared with morphine for pain relief following arthroscopic knee surgery.
To compare the analgesia produced by comparable doses of intra-articular (IA) morphine and fentanyl. ⋯ Better postoperative analgesia was achieved with 50 microg intraarticular fentanyl than with 3 mg intraarticular morphine.
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To review the literature regarding epidural blood patch (EBP) to generate conclusions relating to the controversial issues surrounding its application. ⋯ Blood-patching is an effective treatment of PDPH but further research is required regarding its mechanisms and prophylaxis.
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Randomized Controlled Trial Clinical Trial
Oral clonidine premedication reduces induction dose and prolongs awakening time from propofol-nitrous oxide anesthesia.
To evaluate whether oral clonidine premedication affects the induction dose of propofol and awakening time from epidural and propofol anesthesia. ⋯ Premedication with 5 microg x kg(-1) clonidine p.o. reduced the induction dose of propofol, but delayed emergence from propofol anesthesia.
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Previous experience has suggested that the insertion of an epidural catheter becomes easier when the patient takes a deep breath. The purpose of this study is to investigate the effects of respiration on the epidural space. ⋯ Epiduroscopy showed that deep breathing expanded the potential cavity of the epidural space. We suggest that the changes in the epidural structure during deep breathing may assist in the insertion of an epidural catheter.