Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Randomized Controlled Trial Clinical Trial
Intraoperative high dose fentanyl induces postoperative fentanyl tolerance.
In a randomized, double-blind clinical trial, we compared the postoperative analgesic effect and dose consumption of fentanyl after intraoperative high dose and low dose fentanyl administration. ⋯ Our results suggest that acute fentanyl tolerance develops after administration of high dose fentanyl during surgery and, consequently, results in a higher postoperative pain intensity and greater fentanyl consumption.
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Randomized Controlled Trial Comparative Study Clinical Trial
Intraarticular fentanyl compared with morphine for pain relief following arthroscopic knee surgery.
To compare the analgesia produced by comparable doses of intra-articular (IA) morphine and fentanyl. ⋯ Better postoperative analgesia was achieved with 50 microg intraarticular fentanyl than with 3 mg intraarticular morphine.
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Randomized Controlled Trial Clinical Trial
Oral clonidine premedication reduces induction dose and prolongs awakening time from propofol-nitrous oxide anesthesia.
To evaluate whether oral clonidine premedication affects the induction dose of propofol and awakening time from epidural and propofol anesthesia. ⋯ Premedication with 5 microg x kg(-1) clonidine p.o. reduced the induction dose of propofol, but delayed emergence from propofol anesthesia.