Journal of clinical epidemiology

The most recent articles from: J Clin Epidemiol September 2016

J Clin Epidemiol · Sep 2016

Pragmatic trial design elements showed a different impact on trial interpretation and feasibility than explanatory elements.

To illustrate how pragmatic trial design elements or inserting explanatory trial elements in pragmatic trials affect validity, generalizability, precision, and operational feasibility. ⋯ Consequences of incorporating pragmatic or explanatory trial design elements in pragmatic trials should be explicitly considered and balanced for all relevant domains, including validity, generalizability, precision, and operational feasibility. Tools are needed to make these consequences more transparent.

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