Journal of clinical laboratory analysis
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J. Clin. Lab. Anal. · Mar 2021
Anti-citrullinated protein antibodies are associated with neutrophil extracellular trap formation in rheumatoid arthritis.
We evaluated the associations of anti-citrullinated protein antibodies (ACPAs) and serological and cytological levels of neutrophil extracellular trap (NET) formation in rheumatoid arthritis (RA) patients. ⋯ Anti-citrullinated protein antibodies may enhance NET formation and contribute to inflammation development in RA by stimulating NET formation, such as by subsequent activation of FLS cells by NETs.