Nutrition
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This study investigated the potential beneficial effects of onion extract on brain ischemia-induced edema and blood-brain barrier (BBB) dysfunction. The possible underlying mechanisms are investigated, especially those linked to the antioxidant effects of the onion extract. ⋯ The results from this study demonstrate that onion extract prevents brain edema, BBB hyperpermeability, and tight junction proteins disruption, possibly through its antioxidant effects in the mouse MCAO model. This study suggests that onion extract may be a beneficial nutrient for the prevention of BBB function during brain ischemia.
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Cardiopulmonary bypass (CPB) is responsible for an inflammatory response that can lead to postoperative organ dysfunction. Undernutrition increases the risk of organ failure. We investigated the effect of undernutrition on the inflammatory response and mesenteric vascular reactivity induced by CPB in rats. ⋯ CPB and undernutrition induce mesenteric hypercontractility to α1-adrenergics and impair vascular relaxation, without any additive effect of CPB on undernutrition. Undernutrition causes inflammation and a lack of vascular relaxation, probably involving smooth muscle contractile mechanisms.