Nutrition
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Multicenter Study Clinical Trial
Dietary intake and childhood leukemia: The Diet and Acute Lymphoblastic Leukemia Treatment (DALLT) cohort study.
Children with acute lymphoblastic leukemia (ALL) are at elevated risk for nutrition-related morbidity both during and after therapy. We present the demographic characteristics and nutrient intake at study entry of a prospective cohort in which evaluating dietary intake in children diagnosed with ALL was investigated. ⋯ This study was successful in collecting dietary intake data at the time of cancer diagnosis in a multicenter setting in a pediatric population at high-risk for nutrition-related morbidity. We identified "at-risk" dietary intakes, which vary by sex and ALL risk group; such patients may benefit from future dietary interventions.
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Randomized Controlled Trial
Calcium plus vitamin D supplementation during pregnancy interacts with polymorphisms in the promoter region of the VDR gene to affect postpartum bone mass of Brazilian adolescent mothers: A randomized controlled trial.
We investigated whether calcium plus vitamin D supplementation interacts with polymorphisms in the VDR gene promoter region to affect changes on maternal bone mass from 5 to 20 wk postpartum in Brazilian adolescent mothers. ⋯ Calcium plus vitamin D supplementation during pregnancy interacted with polymorphisms in the VDR gene promoter region affecting postpartum bone loss. The increased supply of calcium and vitamin D appeared to minimize postpartum bone loss particularly in adolescents with 1521 GG/1012 AA.
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Multicenter Study
Nutritional risk screening and clinical outcome assessment among patients with community-acquired infection: A multicenter study in Beijing teaching hospitals.
The aim of this study was to implement nutritional risk screening in patients with community-acquired infection (CAI) and analyze its relationship with clinical outcomes. ⋯ Many patients with CAI were at nutritional risk and tended to worsen during hospitalization, which has been associated with increased LOS and rate of readmission. Nutritional support might be beneficial to the patients by shortening LOS. Inappropriate use of nutritional support was observed in patients with CAI.
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Vitamin D deficiency is a worldwide problem. Although vitamin D has been implicated in muscle development, little is known about the effects of maternal vitamin D status on the muscle development of offspring. The aim of this study was to evaluate the effects of improving maternal vitamin D status by dietary 25-hydroxyvitamin D3 (25 OHD3) supplementation on prenatal and postnatal skeletal muscle development of offspring, using pigs as the model. ⋯ These results suggest that improving maternal vitamin D status by dietary supplementation with 25 OHD3 can promote prenatal and postnatal skeletal muscle development of pig offspring by modulating the expressions of muscle transcription factors.
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Randomized Controlled Trial
Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial.
Previous experimental studies have suggested curcumin as a safe phytochemical that can improve insulin resistance through effects on adiponectin and leptin. This study aimed to investigate the effect of curcumin on circulating adiponectin and leptin concentrations in patients with metabolic syndrome. ⋯ Curcumin can improve serum levels of adiponectin and leptin in patients with metabolic syndrome. This trial was registered at the UMIN Clinical Trials Registry (http://www.umin.ac.jp/ctr/) under Trial No. UMIN000018339.