Nutrition
-
Randomized Controlled Trial
Calcium plus vitamin D supplementation during pregnancy interacts with polymorphisms in the promoter region of the VDR gene to affect postpartum bone mass of Brazilian adolescent mothers: A randomized controlled trial.
We investigated whether calcium plus vitamin D supplementation interacts with polymorphisms in the VDR gene promoter region to affect changes on maternal bone mass from 5 to 20 wk postpartum in Brazilian adolescent mothers. ⋯ Calcium plus vitamin D supplementation during pregnancy interacted with polymorphisms in the VDR gene promoter region affecting postpartum bone loss. The increased supply of calcium and vitamin D appeared to minimize postpartum bone loss particularly in adolescents with 1521 GG/1012 AA.
-
Vitamin D deficiency is a worldwide problem. Although vitamin D has been implicated in muscle development, little is known about the effects of maternal vitamin D status on the muscle development of offspring. The aim of this study was to evaluate the effects of improving maternal vitamin D status by dietary 25-hydroxyvitamin D3 (25 OHD3) supplementation on prenatal and postnatal skeletal muscle development of offspring, using pigs as the model. ⋯ These results suggest that improving maternal vitamin D status by dietary supplementation with 25 OHD3 can promote prenatal and postnatal skeletal muscle development of pig offspring by modulating the expressions of muscle transcription factors.
-
Multicenter Study Clinical Trial
Dietary intake and childhood leukemia: The Diet and Acute Lymphoblastic Leukemia Treatment (DALLT) cohort study.
Children with acute lymphoblastic leukemia (ALL) are at elevated risk for nutrition-related morbidity both during and after therapy. We present the demographic characteristics and nutrient intake at study entry of a prospective cohort in which evaluating dietary intake in children diagnosed with ALL was investigated. ⋯ This study was successful in collecting dietary intake data at the time of cancer diagnosis in a multicenter setting in a pediatric population at high-risk for nutrition-related morbidity. We identified "at-risk" dietary intakes, which vary by sex and ALL risk group; such patients may benefit from future dietary interventions.