Nutrition
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Randomized Controlled Trial Multicenter Study
Tolerance and efficacy of a polyamine-deficient diet for the treatment of perioperative pain.
Polyamines have been identified as pain agonists and interact with N-methyl-D-aspartate receptors. A prospective, randomized, multicenter, and blinded phase II clinical trial was conducted to evaluate a polyamine-deficient diet for the treatment of perioperative pain in patients during spinal surgery. ⋯ Suppression of polyamines from the diet offers a nutrition-based treatment option for perioperative pain reduction independent of and complementary to typical analgesic approaches.