Nutrition
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Randomized Controlled Trial
Water supplementation affects the fluid intake and serum levels of BDNF among the elderly nursing home residents.
The link between dehydration and fluid intake with brain function in elderly individuals has produced conflicting findings. The aim of this study was to examine the effects of water supplementation on fluid intake, cognitive and motor performance, and serum brain-derived neurotrophic factor (BDNF) levels in euhydrated and dehydrated elderly. ⋯ The present study demonstrated that 7 d of water supplementation increased the water and the total fluid intake in elderly individuals regardless of dehydration status. Serum BDNF levels increased during dehydration and reverted to physiologic levels after appropriate rehydration.
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Randomized Controlled Trial
Intermittent fasting activates markers of autophagy in mouse liver, but not muscle from mouse or humans.
Intermittent fasting (IF) activates autophagy in cardiac muscle and pancreatic islets. We examined the effect of IF on markers of autophagy in liver and skeletal muscle in mice and in humans. ⋯ Markers of autophagy in liver, but not in muscle, were elevated in response to IF in mice. In humans, autophagy markers in muscle were reduced, likely in response to weight loss.
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Intake of dietary fibers promotes the production of short-chain fatty acids (SCFAs), which can affect host inflammation via gut microbial fermentation. Although partially hydrolyzed guar-gum (PHGG) is a water-soluble dietary fiber with lower viscosity, its benefits in acute inflammation are yet to be determined. The aim of this study was to investigate the effect of PHGG intake on the lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production. ⋯ These results demonstrated that inflammation was inhibited by habitual PHGG ingestion, suggesting that this phenomenon might be associated with changes in gut microbiota-induced SCFAs production.
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The present study aimed to evaluate the effects of maternal protein restriction during pregnancy on the lungs of 1-d and 31-d old offspring of C57BL/6 mice. ⋯ Protein restriction during pregnancy reduces the body weight of offspring and promotes inflammation and oxidative stress, resulting in a simplification of the lung structure.
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Randomized Controlled Trial
The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial.
Poor vitamin D and magnesium status is observed in individuals who are overweight and obese (Owt/Ob) and is often associated with a heightened risk of cardiovascular disease. Magnesium is a cofactor that assists vitamin D metabolism. We aimed to determine the efficacy of a combined magnesium and vitamin D regimen compared with vitamin D only on increasing serum 25-hydroxyvitamin D (25OHD) concentrations and the effects of these supplements on cardiometabolic outcomes. ⋯ A combined MagD treatment may be more effective in increasing serum 25OHD concentrations compared with VitD supplementation alone in Owt/Ob individuals.