Reproductive toxicology
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Reproductive toxicology · Jun 2019
Meta AnalysisUse of ondansetron during pregnancy and the risk of major congenital malformations: A systematic review and meta-analysis.
To investigate whether ondansetron use during pregnancy is associated with increased rates of major or subgroups of malformations. ⋯ Ondansetron use during pregnancy was not associated with a significant increase in rate of major or selected subgroups of malformations in our primary analysis. However, results of the secondary analyses warrant the need for continued surveillance. These results may be reassuring for pregnant women in whom ondansetron use is clinically indicated since the absolute risks of possible concerns appear to be low.
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Reproductive toxicology · Apr 2015
Review Meta AnalysisExposure to fluconazole and risk of congenital malformations in the offspring: A systematic review and meta-analysis.
Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, mostly during the reproductive age, and recurrence rate is about 50%. Because half of all pregnancies are unplanned and pregnant women have an increased risk of VVC recurrence, the likelihood of inadvertently being exposed to fluconazole in pregnancy is increased. ⋯ In conclusion, the use of fluconazole in the first trimester does not appear to increase the overall risk for congennital malformations. More studies are needed to address the potential increased rate of heart defects.