Journal of clinical anesthesia
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Randomized Controlled Trial Clinical Trial
The minimum alveolar concentration (MAC) of sevoflurane with and without nitrous oxide in elderly versus young adults.
To determine the minimum alveolar concentration (MAC) of sevoflurane with and without 65% nitrous oxide (N2O) in non-Asian patients at least 70 years of age, and in patients aged 18 to 35 years. ⋯ The MAC of sevoflurane determined in this study is similar to that determined in previous studies, including the MAC determined in an elderly Asian population. Increasing age and N2O decrease sevoflurane MAC similarly to that determined with other volatile anesthetics.
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To evaluate the perioperative risk to nonparturients with Eisenmenger's physiology for noncardiac surgical procedures. ⋯ A variety of anesthetic techniques and drugs may be used successfully in nonparturients with Eisenmenger's physiology undergoing noncardiac surgery. Although the study group is small, the perioperative mortality risk is lower than that for parturients undergoing either labor and delivery or cesarean section and is probably in the range of approximately 10%.
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The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known. However, a method to differentiate the neuromuscular block induced by magnesium from that induced by curariform nondepolarizing muscle relaxant in the clinical setting has never been reported. ⋯ We believe this is a remarkable potentiation on record in the literature. We also describe a new, noninvasive method to assess magnesium-induced neuromuscular block when curariform muscle relaxant was given simultaneously.
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Randomized Controlled Trial Comparative Study Clinical Trial
Rocuronium priming of atracurium-induced neuromuscular blockade: the use of short priming intervals.
To evaluate the effects of priming doses of rocuronium on the duration of priming interval and on the outcome of priming sequence using rocuronium-atracurium combination. ⋯ Priming doses of recuroniums 0.1 mg/kg reduce the priming interval to 1 minute, allow early induction of anesthesia, eliminate patient discomfort, and accelerate the onset time of altracurium with intubating conditions comparable with succinylcholine and rocuronium.
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Randomized Controlled Trial Clinical Trial
Effect of varying intravenous patient-controlled analgesia dose and lockout interval while maintaining a constant hourly maximum dose.
To investigate the effect on the use of intravenous patient-controlled analgesia (PCA) of varying the dose (D) and lockout interval (LI) while keeping the hourly maximum dose constant. ⋯ The use of 1.0 mg with a 6-minute lockout may represent appropriate dose titration because this group obtained equivalent analgesia, morphine use, and side effects as the two larger dose and lockout groups. However, the increased number of PCA attempts and missed attempts may reflect lower satisfaction with PCA therapy.